Molecular channels that control the movement of ions in and out of cells profoundly influence what a cell does. Many different ion channels have been discovered, but the ones that fascinate Christopher Poll, Unit Head at the Novartis Institutes for BioMedical Research in Horsham, UK, are called transient receptor potential (TRP) channels. “We believe calcium influx through TRP channels in cells that modulate inflammation plays a key role in many diseases, ” said Chris. In particular, Chris is investigating which of the several different TRP channels expressed by almost all inflammatory cells involved in respiratory diseases such as asthma and chronic obstructive pulmonary disease may be suitable drug targets.
TRP channels are made up of different subunits, and these subunits can combine with one another in a variety of ways. The complexity of TRP channel subunit interactions and how that may determine a channel’s role in regulating cellular calcium level in different cells amazes Chris. “Once we identify the specific TRP channels involved in inflammation, we’ll be screening for compounds that inhibit those channels to test our hypothesis,” said Chris. It’s undesirable to interfere with the activity of TRP channels that may serve to maintain normal cell functions because that could cause side effects.
Chris is confident that specific channel blockers will be found that can be tested. It’s a continuation of a process that began centuries ago. The discovery and development of medicine and how people have learned to use medicinal plants has always interested Chris. “Our methods are light-years ahead of what our ancestors did, and we’re far more advanced than we were even 20-30 years ago,” said Chris, “For me it’s a privilege to be involved.” The basic premise, however, remains the same – finding new ways to cure or relieve those suffering of disease.
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